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Old 06-07-2006, 09:17 PM Vienge. is offline  
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curdledvomit
 
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this from http://www.recombinomics.com/News/06...nesia_RBD.html



Commentary


Altered Receptor Binding in H5N1 Bird Flu in Indonesia?


Recombinomics Commentary
June 8, 2006

This difficulty was caused by two matters that is receptor relations and spesifisitas the receptor and the difference of the temperature between the person and the poultry also were different.

Therefore, I carried out the research in the month February-March 2006.

This research was helped by Tokyo University.

The aim of the research to know whether the circulating virus in the field, only had the shape of the virus from the poultry that is had spesifisitas the receptor alfa 2,3 or that had spesifisitas the receptor alfa 2,6 that is the virus that could infect direct to the mammal (the pig and humankind, etc..)
.
The sample that I the test came from the poultry, the pig, and humankind.

From 100 samples, there is 20 that succeeded in being turned on and evidently 11 among them had spesifisitas the receptor 2,6.

Meaning that, these viruses had the capacity immediately could infect humankind without must from the poultry before.

Moreover, some of the samples had the amino acid lisin in the number 627 proteins PB2, that meaning that the virus could be stable in the temperature of the human body.

The above translation of an interview with CA Nidom from the Airlangga University Vetereinary School in Surabaya is cause for concern. The comments indicate that 20% of the samples tested had virus (presumably H5N1) and 55% of the positives had a 2,6 receptor specificity, indicating they had an increased affinity for human receptors in the upper respiratory tract. In addition, many had PB2 E627K, which allows the H5N1 to grow at lower temperatures.

Earlier reports described E627K in one of the initial samples from Jakarta, A/Indonesia/6/2005(H5N1). There was additional speculation that the high levels of H5N1 bird flu in the nose and throat of victims in Medan were also due to E627K.

The above comments indicates thee are differences in receptor specificities in the H5N1 isolates from Jakarta. The comments above to not break down the number of H5N1's with 2.6 specificities, but H5N1 can readily recombine and exchange such information, so finding that specificity in H5N1 in any of the tested species is cause for concern.

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Old 06-08-2006, 06:41 PM curdledvomit is offline  
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this from http://www.vnagency.com.vn/NewsA.asp...NEWS_ID=202835



Indonesia admits cases of human transmission of bird flu
06/10/2006 -- 22:08(GMT+7)

Jakarta (VNA) - An Indonesian minister on June 9 said that human-to-human transmission of bird flu probably occurred in the country's seven cluster cases, but ruled out a pandemic of H5N1 across the country.

"Limited human-to-human transmission may have occurred in small clusters in the country," Jakarta Post quoted Coordinating Minister for the People's Welfare Aburizal Bakrie as saying, following a meeting with agencies involved in curbing the spread of the disease.

Experts were puzzled by a seven-member cluster in Indonesia's Sumatra village in May, which led to speculation that human-to-human transmission had occurred among family members.

However, Aburizal emphasized that the public should not be concerned because it was not a pandemic, and the transmission of the virus continued to be from poultry.

Indonesia has had 37 fatalities from 50 confirmed human cases of bird flu, the paper said, adding that poultry infections have been recorded in 29 of 33 provinces.-Enditem
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Old 06-11-2006, 08:43 AM curdledvomit is offline  
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this from http://www.ctv.ca/servlet/ArticleNew...hub=TopStories


H5 avian virus found in PEI goose: initial test

Updated Fri. Jun. 16 2006 11:38 PM ET

Canadian Press

TORONTO -- A domestic goose that died in western Prince Edward Island this week tested positive for an H5 avian influenza virus, the Canadian Food Inspection Agency confirmed Friday.

Samples are being sent to the CFIA's National Centre for Foreign Animal Diseases in Winnipeg so that confirmatory tests can be run and the neuraminidase (the N in a flu virus's name) can be determined.

Results of those tests aren't expected until Monday or Tuesday at the earliest, said Dr. Jim Clark, the CFIA's director of animal health. But Clark said there are already clues this avian flu virus isn't likely the highly pathogenic H5N1 virus that has decimated chicken flocks in parts of Asia.

That's because the goose was part of a small, free-range flock of chickens, geese and ducks. And while four of 11 geese in the flock died, none of the chickens fell ill.

"If this is a highly pathogenic virus -- or it was -- then it should have been causing some difficulty for the chickens,'' Clark said in an interview from Ottawa.

"So we're relatively confident that the virus has low pathogenicity. But we won't be able to say that definitely until the lab in Winnipeg finishes analyzing the samples."

Clark said there's actually no evidence at this point that avian flu played a role in the death of the geese.

"Just because these birds have died, we mustn't jump to the conclusion it was an influenza virus that killed them," he cautioned.

A post-mortem examination of the bird will be done to determine the cause of death. The other birds in the flock -- killed as a precautionary measure -- will also be examined for presence of the virus.

A spokesperson for the Public Health Agency of Canada said at the request of provincial authorities, the agency is sending three epidemiologists to Prince Edward Island to help in the investigation and to help monitor the health of people who came in contact with the flock.

"Based on the information that we have at this point in time . . . there is no new threat to human health,'' said Aggie Adamczyk.

"But while we wait for the results of further testing . . . precautions are being taken to protect the health of those who have been in close contact with birds."

Dr. Lamont Sweet, P.E.I.'s chief medical officer, said people in the vicinity will be monitored for flu-like symptoms or eye infections.

Although H5N1 causes severe infection and often death in humans, most avian flu viruses induce no human disease or at worst conjunctivitis.

The owner of the birds, who was raising them for personal consumption, told authorities he noticed four of his geese were "walking funny" on Sunday.

"Monday morning, he came out (and) the four birds that were walking funny were dead,'' Clark said.

The man disposed of three but took one for testing to the Atlantic Veterinary College in Charlottetown. The laboratory there confirmed the presence of an H5 virus.

Further testing will reveal the nature of the virus. But an avian influenza expert agreed the fact the chickens in this flock didn't fall ill suggests it probably isn't a highly pathogenic H5 virus.

"It certainly doesn't sound like the Asian H5N1,'' said Dr. Ted Leighton, executive director of the Canadian Co-operative Wildlife Health Centre.

H5 and H7 avian flu viruses come in two forms -- highly pathogenic and low pathogenicity or high and low path for short. The former is deadly to domestic chickens while the latter typically leads to a drop off in egg production.

"There's no such thing as zero probability on these things. But there's a lot of other reasons why a bunch of geese might die,'' Leighton said.

The geese were purchased about six weeks ago from a local co-operative. Clark said a trace-back is underway to see where the birds came from. "We're very interested in the source of the birds.

"(But) having said that, six weeks ago is too long for the birds to incubate the virus,'' he said, suggesting it is more likely the geese picked up the virus after coming in contact with wild birds.

A wild bird surveillance program conducted in Canada last fall found a number of birds carrying low path H5 viruses. Analysis of the genetic blueprints of the viruses showed none were of the Asian H5N1 lineage and posed little or no threat to human health.

The CFIA is not putting movement restrictions in place in the area, noting there are no large commercial poultry operations within a 10-kilometre radius and few small poultry holdings nearby.

International codes require countries to notify the World Organization for Animal Health -- known as the OIE -- when they discover H5 and H7 viruses in birds. If the Winnipeg lab confirms the H5 finding, the CFIA will notify the Paris-based agency as well as trading partners, Clark said.
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Old 06-17-2006, 11:12 AM curdledvomit is offline  
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THIS JUST IN


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Old 06-17-2006, 11:16 AM growler is offline  
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Old 06-17-2006, 11:20 AM Vienge. is offline  
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i read this whole thread thinking it was current; i feel so violated
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Old 06-17-2006, 01:00 PM Tenacious N is offline  
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this from http://www.cidrap.umn.edu/cidrap/con...06cluster.html


H5N1 mutation showed human transmission in Indonesia


Jun 23, 2006 (CIDRAP News) The recent family cluster of H5N1 avian influenza cases in Indonesia marks the first time laboratory tests confirmed human-to-human transmission, the World Health Organization (WHO) told reporters today.

According to news reports, WHO officials said the virus mutated slightly when it infected a 10-year-old boy, and he passed the altered virus on to his father. Detection of the altered strain in both the boy and his father was evidence of direct transmission.

The mutation did not make the virus more transmissible, and the boy's father, who died of the illness, did not pass it on to anyone else, WHO officials were quoted as saying.

"We've never really had a fingerprint to confirm human-to-human transmission like we had here," said WHO spokesman Dick Thompson, as reported by Agence France-Presse (AFP) today.

Human-to-human transmission has been suspected in a number of previous family case clusters but has never been confirmed by lab tests. Previously, either there were no samples available to test, or the virus in the patients was the same as in local poultry, according to an International Herald Tribune report today.

The family cluster last month in North Sumatra involved seven confirmed cases, six of them fatal. The cluster is believed to have started with a 37-year-old woman who died and was buried without being tested for the disease. Officials believe she caught the virus from poultry and passed it on to other family members.

WHO report not released to press
The WHO discussed some of its findings concerning the cluster at the end of a 3-day meeting in Jakarta today, according to reports. The agency presented a report on the cluster to the Indonesian government without releasing it to the news media. But the Associated Press (AP) said it had obtained a copy.

According to the International Herald Tribune report, the first five family members who got sick had identical strains of H5N1, one that is common in animals in Indonesia. But the virus mutated slightly in the 10-year-old boy.

Thompson described the virus as "slightly mutated, but in a way that viruses commonly mutate," the story said. "But that didn't make it more transmissible or cause more severe disease," he said.

Health officials have previously described the case cluster as the first instance of a probable three-person chain of transmission (two generations of transmission).

Tim Uyeki of the US Centers for Disease Control and Prevention said the findings about the boy passing the virus to his father provide evidence of that occurrence, according to an AP report published today.

Officials gave no details today on the mutation that was observed in the H5N1 strain found in the boy and his father.

According to Bloomberg news, a 7-page summary report on the investigation said genetic analyses of viruses from the family cluster showed no evidence of reassortment, or combination of avian and human flu viruses.

Keiji Fukuda, director of the WHO's global influenza program, told reporters that the case cluster prompted the WHO to consider whether to move into a pandemic alert, according to a Reuters report today.

"The answer is clearly no," he said. "We see no evidence of the start of pandemic influenza."

Avian flu widespread in Indonesia
However, H5N1 avian flu is widespread in Indonesia, experts said in a statement released at the end of the Jakarta meeting. The statement said the government should focus on detection of human case clusters, according to the Reuters report.

"Highly pathogenic H5N1 avian influenza is widespread and well established in Indonesia but the full extent is unknown," the statement said. "It is believed that large numbers of animal infections are undetected.

"The public is still lacking basic knowledge of the risks to their poultry and themselves and therefore their understanding of control methods in poultry and how to protect themselves is minimal."

Jeff Mariner, a Tufts University researcher who attended the meeting, said avian flu is more pervasive in Indonesia's poultry than previously thought, according to an AP story.

Mariner is coordinating a United Nations Food and Agriculture Organization effort to train local avian flu surveillance teams. In 12 pilot districts on Java Island, the teams detected 78 poultry outbreaks from January through May, with about one out of every 10 interviews revealing an outbreak, Mariner told the AP.

Because of a lack of personnel, the surveillance covered only about a third of each district, he said.
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Squid posted..."curdledvomit is the first +10k guy i actually care about"

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Old 06-23-2006, 07:54 PM curdledvomit is offline  
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Vienge.
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Finally, are millions gonna die now?
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Old 06-23-2006, 07:56 PM Vienge. is offline  
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#775  

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where the fuck is birdflu
i want that shit
Old 06-23-2006, 07:57 PM aoeoae is offline  
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Old 06-23-2006, 07:57 PM awesomepossum is offline  
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Quote:
Originally Posted by g's ass
Pope has birdflu
 He got it from the cardinals 
Old 06-23-2006, 07:58 PM aoeoae is offline  
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#778  

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Quote:
Originally Posted by curdledvomit
this from http://www.ctv.ca/servlet/ArticleNew...hub=TopStories


H5 avian virus found in PEI goose: initial test

PEI?

That's only a few thousand kilometers away.
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Old 06-23-2006, 07:58 PM Bob Ewbanks is offline  
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Quote:
Originally Posted by Vienge.
Finally, are millions gonna die now?

I think so
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Old 06-23-2006, 07:59 PM curdledvomit is offline  
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